Results from the cross-sectional zero-inflated negative binomial (ZINB) regression analysis of the Larsen score on the carriage of at least 1 copy of the shared epitope single-nucleotide polymorphism (SNP).
| Gene, SNP | Cohort | Year | Model | No. Patients | Estimate | Lo95 | Up95 | p | Comb p |
|---|---|---|---|---|---|---|---|---|---|
| HLA-DRB1 Shared epitope | ERAS | 3 | ZINB severity | 327 | 0.36 | 0.02 | 0.83 | 3.85 E-02 | 6.38 E-05 |
| ZINB susceptibility | 4.43 | 2.02 | 9.70 | 1.99 E-04 | |||||
| NBREG | 207 | 0.46 | 0.04 | 1.05 | 3.02 E-02 | — | |||
| LOGIT | 394 | 2.51 | 1.55 | 4.05 | 1.73 E-04 | ||||
| NOAR | 5 | ZINB severity | 589 | 0.84 | 0.46 | 1.31 | 1.99 E-07 | 1.26 E-07 | |
| ZINB susceptibility | 1.35 | 0.80 | 2.28 | 2.55 E-01 | |||||
| NBREG | 260 | 0.29 | 0.06 | 0.56 | 1.00 E-02 | — | |||
| LOGIT | 593 | 2.50 | 1.76 | 3.54 | 2.55 E-07 |
Est: estimate, expressed as percentage increase in Larsen score for the severity part of the model, or as OR for the susceptibility part of the model; Lo95: lower 95% CI; Up95: upper 95% CI; comb p: ZINB combined p value; NOAR: Norfolk Arthritis Register; ERAS: Early Rheumatoid Arthritis Study; NBREG: negative binomial regression; LOGIT: logistic regression.