Changes in skin histopathological measures (dorsal side of forearm).
| Variable | 0M, n = 8 | 3M, n = 8 | 12M, n = 7 | 24M, n = 7 | p | ||||
|---|---|---|---|---|---|---|---|---|---|
| Hyalinized collagen score, mean, SD | 69.3 | 22.8 | 44.4 p = 0.05 | 34.7 | 23.9* p = 0.002 | 28.8 | 33.1† p = 0.025 | 27.0 | 0.009 (MMA) |
| Myofibroblast positivity, frequency (%) | 8/8 (100) | 4/8 (50) p = 0.125** | 1/7† (14) p = 0.031** | 1/7† (14) p = 0.031** | 0.005 (Cochran) | ||||
| B cell positivity, frequency (%) | 4/8 (50) | 0/8 (0) p = 0.125** | 0/7 (0) p = 0.125** | 1/7 (14) p = 0.250** | p = 0.031 (Cochran) |