Table 1.

Main studies of laser Doppler monitoring and capillaroscopy to evaluate microvascular damage in patients with systemic sclerosis (SSc).

StudyNo. PatientsMethodsMain Findings
Correa244LDI and NFCLDI and NFC are complementary tools for evaluation of different aspects of SSc microangiopathy
Cutolo334LDF and NVCFingertip blood perfusion correlated negatively with the extent of the nailfold microvascular damage scored according to NVC classification
Rosato5142LDI and NVCSkin blood perfusion showed a negative correlation with microvascular damage scored according to NVC classification
Rosato630LDI and NVCIn SSc patients with pulmonary arterial hypertension, bosentan improved skin perfusion, particularly in patients with the early/active capillaroscopic patterns
Rosato7100LDI, NVC, and PPGA strong correlation exists between capillaroscopic patterns and digital skin perfusion and pulsatility of digital arteries
Murray816LDI, NFC, and thermal imagingLDI and thermal imaging give equivalent information on dynamic changes in the cutaneous microcirculation. However, a combination of all 3 techniques improves classification
Mugii9127NVCRed blood cell velocity was significantly associated with NVC findings. Patients with the scleroderma active and late NVC pattern showed a lower red blood cell velocity compared with scleroderma early pattern
Rosato1040LDI and NVCIn early SSc, thermoregulation of finger skin is impaired. With progression of NVC damage, the abnormal microvascular response to cold stimulation also appears in the hand dorsum skin
  • LDI: laser Doppler imaging; LDF: laser Doppler flowmetry; NFC: nailfold capillaroscopy; NVC: nailfold videocapillaroscopy; PPG: photoplethysmography.