Multivariate linear regression analyses at baseline (T0), 2-year followup (T2y), and 5-year followup (T5y) with WOMAC function (0–100 scale) as dependent variable. Difference refers to knee and contralateral knee and sum to left + right knee.
| ß (95% CI) | p | |
|---|---|---|
| Radiographic feature T0 | ||
| Osteophyte area (sum) | 3.89 (0.52, 7.26) | 0.02 |
| Bone density (difference) | −1.08 (−2.09, −0.06) | 0.04 |
| Demographic | ||
| BMI T0 | 0.92 (0.32, 1.53) | 0.003 |
| Radiographic feature T2y | ||
| Osteophyte area (difference) | −8.26 (−15.53, −1.00) | 0.03 |
| Demographic | ||
| BMI T2y | 1.33 (0.85, 1.80) | < 0.0001 |
| ESR T0 | 0.40 (0.12, 0.68) | 0.01 |
| Radiographic feature T5y | ||
| Minimum JSW (sum) | −1.45 (−2.39, −0.51) | 0.003 |
| Osteophyte area (sum) | 2.76 (0.06, 5.46) | 0.05 |
| Demographic | ||
| BMI T5y | 0.85 (0.43, 1.27) | < 0.0001 |
| ESR T0 | 0.38 (0.08, 0.69) | 0.01 |
WOMAC: Western Ontario and McMaster Universities Osteoarthritis Index for pain; ß: regression coefficient; JSW: joint space width; BMI: body mass index; ESR: erythrocyte sedimentation rate.