Table 1.

Clinical characteristics of the mutation-positive patients.

Patient No. and Origin	Sex	Age, yrs	Episodes with TRAPS-related Symptoms	Acute-phase Response Markers	Autoimmune Disease	Family History	Therapy
IP1
German	F	22	Arthralgias, migraine, mild fever episodes, of fatigue	Intermittent elevation TNF-α, ESR, CRP, SAA	RRMS	Pos	NSAID
F1
German	M	50	Migraine, fatigue	NK	RRMS		None
S1.1
German	F	19	Arthralgias, abdominal pain, bifrontal headaches	Intermittent elevation of TNF-α, CRP, SAA	None		NSAID
S1.2
German	F	9	Abdominal pain	Intermittent elevation of CRP, ESR, SAA	None		None
B1
German	M	11	Arthralgias	ESR elevation	None		None
IP2
Austrian	F	28	Arthralgias, arthritis, abdominal pain, diarrhea, conjunctivitis	Intermittent elevation of CRP, ESR, SAA, TNF-α, IL-6, RF-positive	RA, RRMS	Pos	NSAID, oral steroids, MTX, LEF
D2
Austrian	F	8	Arthralgias, abdominal pain, diarrhea	NK	None		None
IP3
German	F	37	Arthralgias, myalgias, eyelid edema, bifrontal headaches, abdominal pain, fatigue	CRP, ESR, SAA normal	RRMS	Pos^*	NSAID, oral steroids, glatiramer acetate (for RRMS)

↵* Index patient 3 family history with RA in 1 grandmother, 2 sisters with arthralgias, 1 sister with possible MS. IP: index patient; F: father; S: sister; B: brother; D: daughter (for example, S1.1 = first sister of index patient 1); CRP: C-reactive protein; SAA: serum amyloid A; ESR: erythrocyte sedimentation rate; RF: rheumatoid factor; IL-6: interleukin 6; TNF-α: tumor necrosis factor; RRMS: relapsing-remitting multiple sclerosis; RA: rheumatoid arthritis; NK: not known; NSAID: nonsteroidal antiinflammatory drug.