Association of antiphospholipid assays with a history of lupus anticoagulant (LAC).
| Assay | LAC-positive, n = 71 No. (% positive) | LAC-negative n = 212 No. (% positive) | OR (95% CI) | p | |
|---|---|---|---|---|---|
| Anti-PS/PT | IgM | 35 (49) | 16 (8) | 11.9 (6.0, 23.7) | < 0.0001 |
| IgG | 26 (37) | 8 (4) | 14.7 (6.3, 34.7) | < 0.0001 | |
| IgG/M | 34 (48) | 16 (8) | 11.3 (5.6, 22.4) | < 0.0001 | |
| Anticardiolipin | IgM | 17 (24) | 10 (5) | 6.4 (2.8, 14.7) | < 0.0001 |
| IgG | 20 (28) | 9 (4) | 8.8 (3.8, 20.6) | < 0.0001 | |
| IgA | 10 (14) | 0 (0) | < 0.0001 | ||
| Anti-ß2-GPI | IgM | 10 (14) | 4 (2) | 8.5 (2.6, 28.1) | < 0.0001 |
| IgG | 16 (23) | 3 (1) | 20.3 (5.7, 72.1) | < 0.0001 | |
| IgA | 29 (41) | 30 (14) | 4.2 (2.3, 7.7) | < 0.0001 | |
| Anti-ß2-GPI D1 | IgG | 9 (13) | 5 (2) | 6.0 (1.9, 18.6) | 0.0005 |
| Anti-ß2-GPI D4/5 | IgA | 21 (30) | 35 (17) | 2.1 (1.1, 4.0) | 0.0167 |
Anti-PS/PT: antiphosphatidylserine/prothrombin; anti-ß2-GPI: anti-ß2-glycoprotein I; anti-ß2-GPI D1: anti-ß2-glycoprotein I domain 1; anti-ß2-GPI D4/5: anti-ß2-glycoprotein I domain 4/5.