Genotype, n (%) | Allele Test | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
CHR | SNP | Locus | 1/2 | Subgroup (n) | 1/1 | 1/2 | 2/2 | MAF, % | p* | pFDR** | OR (95% CI)*** |
7 | rs2069827 | IL6 | G/T | Controls (376) | 305 (81.12) | 68 (18.09) | 3 (0.80) | 9.84 | |||
SSc (420) | 363 (86.43) | 54 (12.86) | 3 (0.71) | 7.14 | 0.05 | 0.16 | 0.70 (0.49–1.01) | ||||
lcSSc (316) | 273 (86.39) | 40 (12.66) | 3 (0.95) | 7.28 | 0.09 | 0.27 | 0.72 (0.49–1.06) | ||||
dcSSc (104) | 90 (86.54) | 14 (13.46) | 0 (0.00) | 6.73 | 0.17 | 0.25 | 0.66 (0.37–1.20) | ||||
ACA+ (160) | 144 (90.00) | 14 (8.75) | 2 (1.25) | 5.63 | 0.02 | 0.07 | 0.55 (0.32–0.93) | ||||
ATA+ (58) | 51 (87.93) | 7 (12.07) | 0 (0.00) | 6.03 | 0.19 | 0.28 | 0.59 (0.26–1.31) | ||||
7 | rs1800795 | IL6 | G/C | Controls (373) | 120 (32.17) | 184 (49.33) | 69 (18.50) | 43.16 | |||
SSc (434) | 168 (38.71) | 189 (43.55) | 77 (17.74) | 39.52 | 0.14 | 0.21 | 0.86 (0.71–1.05) | ||||
lcSSc (323) | 122 (37.77) | 143 (44.27) | 58 (17.96) | 40.09 | 0.25 | 0.37 | 0.88 (0.71–1.09) | ||||
dcSSc (111) | 46 (41.44) | 46 (41.44) | 19 (17.12) | 37.84 | 0.16 | 0.25 | 0.80 (0.59–1.09) | ||||
ACA+ (169) | 55 (32.54) | 86 (50.89) | 28 (16.57) | 42.01 | 0.72 | 0.91 | 0.95 (0.74–1.24) | ||||
ATA+ (59) | 23 (38.98) | 25 (42.37) | 11 (18.64) | 39.83 | 0.50 | 0.50 | 0.87 (0.59–1.30) | ||||
7 | rs2069840 | IL6 | C/G | Controls (376) | 157 (41.76) | 171 (45.48) | 48 (12.77) | 35.51 | |||
SSc (435) | 179 (41.15) | 207 (47.59) | 49 (11.26) | 35.06 | 0.85 | 0.85 | 0.98 (0.80–1.20) | ||||
lcSSc (325) | 129 (39.69) | 161 (49.54) | 35 (10.77) | 35.54 | 0.99 | 0.99 | 1.00 (0.80–1.25) | ||||
dcSSc (110) | 50 (45.45) | 46 (41.82) | 14 (12.73) | 33.64 | 0.61 | 0.61 | 0.92 (0.67–1.26) | ||||
ACA+ (166) | 61 (36.75) | 91 (54.82) | 14 (8.43) | 35.84 | 0.91 | 0.91 | 1.02 (0.78–1.33) | ||||
ATA+ (62) | 33 (53.23) | 23 (37.10) | 6 (9.68) | 28.23 | 0.11 | 0.28 | 0.71 (0.47–1.09) |