Pooled analysis of rs2069827-rs1800795-rs2069840 allelic combinations in white patients with lcSSc and healthy controls.
| Haplotype | lcSSc, n (%), n = 3765 | Controls, n (%), n = 6448 | pMH | p (covariates sex and population) | OR (95% CI) | pBD |
|---|---|---|---|---|---|---|
| GGC | 1073 (28.5) | 1710 (26.5) | 0.016* | 0.014 | 1.14 (1.04–1.25) | 0.36 |
| GCC | 1176 (30.2) | 1915 (29.7) | 0.180 | 0.149 | 1.06 (0.97–1.17) | 0.69 |
| GGG | 1228 (32.6) | 2289 (35.5) | 0.024* | 0.001 | 0.89 (0.81–0.97) | 0.40 |
| TCC | 288 (7.6) | 534 (8.3) | 0.160* | 0.185 | 0.85 (0.73–0.99) | 0.60 |
pMH: allelic Mantel-Haenszel fixed-effects model. pBD: Breslow-Day value.
↵* Multiple testing Bonferroni correction (× 4 analyzed haplotypes). lcSSc: limited cutaneous systemic sclerosis.