Genotype, n (%) | Allele Test | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
CHR | SNP | Locus | 1/2 | Subgroup (n) | 1/1 | 1/2 | 2/2 | MAF, % | p* | pFDR** | OR (95% CI)*** |
7 | rs2069827 | IL6 | G/T | Controls (268) | 206 (76.87) | 59 (22.01) | 3 (1.12) | 12.13 | |||
SSc (254) | 208 (81.89) | 38 (14.96) | 8 (3.15) | 10.63 | 0.45 | 0.67 | 0.86 (0.59–1.26) | ||||
lcSSc (184) | 150 (81.52) | 28 (15.22) | 6 (3.26) | 10.87 | 0.56 | 0.83 | 0.88 (0.58–1.34) | ||||
dcSSc (70) | 58 (82.86) | 10 (14.29) | 2 (2.86) | 10.00 | 0.49 | 0.73 | 0.81 (0.44–1.48) | ||||
ACA+ (71) | 60 (84.51) | 10 (14.08) | 1 (1.41) | 8.45 | 0.22 | 0.66 | 0.67 (0.35–1.38) | ||||
ATA+ (44) | 35 (79.55) | 6 (13.64) | 3 (6.82) | 13.64 | 0.69 | 0.69 | 1.14 (0.59–2.22) | ||||
7 | rs1800795 | IL6 | G/C | Controls (273) | 83 (30.40) | 138 (50.55) | 52 (19.05) | 44.32 | |||
SSc (252) | 81 (32.14) | 117 (46.43) | 54 (21.43) | 44.64 | 0.92 | 0.92 | 1.01 (0.79–1.29) | ||||
lcSSc (181) | 56 (30.94) | 87 (48.07) | 38 (20.99) | 45.03 | 0.83 | 0.83 | 1.03 (0.79–1.34) | ||||
dcSSc (71) | 25 (35.21) | 30 (42.25) | 16 (22.54) | 43.66 | 0.89 | 0.89 | 0.97 (0.67–1.41) | ||||
ACA+ (69) | 25 (36.23) | 31 (44.93) | 13 (18.84) | 41.30 | 0.52 | 0.74 | 0.88 (0.61–1.29) | ||||
ATA+ (44) | 11 (25.00) | 21 (47.73) | 12 (27.27) | 51.14 | 0.23 | 0.54 | 1.32 (0.84–2.06) | ||||
7 | rs2069840 | IL6 | C/G | Controls (270) | 128 (47.41) | 114 (42.22) | 28 (10.37) | 31.48 | |||
SSc (255) | 138 (54.12) | 95 (37.25) | 22 (8.63) | 27.25 | 0.13 | 0.40 | 0.82 (0.62–1.06) | ||||
lcSSc (184) | 98 (53.26) | 70 (38.04) | 16 (8.70) | 27.72 | 0.22 | 0.67 | 0.83 (0.62–1.12) | ||||
dcSSc (71) | 40 (56.34) | 25 (35.21) | 6 (8.45) | 26.06 | 0.21 | 0.63 | 0.77 (0.51–1.16) | ||||
ACA+ (70) | 34 (48.57) | 30 (42.86) | 6 (8.57) | 30.00 | 0.74 | 0.74 | 0.93 (0.62–1.40) | ||||
ATA+ (45) | 25 (55.56) | 16 (35.56) | 4 (8.89) | 26.67 | 0.36 | 0.54 | 0.79 (0.48–1.31) |