Pooled analysis of rs2069827-rs1800795-rs2069840 allelic combinations in white patients with dcSSc and healthy controls.
| Haplotype | dcSSc, n (%), n = 1822 | Controls, n (%), n = 6448 | pMH | p (covariates sex and population) | OR (95% CI) | pBD |
|---|---|---|---|---|---|---|
| GGC | 525 (28.8) | 1710 (26.5) | 0.080* | 0.064 | 1.16 (1.03–1.30) | 0.09 |
| GCC | 518 (28.4) | 1915 (29.7) | 0.171 | 0.494 | 0.92 (0.82–1.04) | 0.9 |
| GGG | 648 (35.6) | 2289 (35.5) | 0.642 | 0.806 | 1.03 (0.92–1.15) | 0.14 |
| TCC | 131 (7.2) | 534 (8.3) | 0.080* | 0.089 | 0.78 (0.64–0.96) | 0.24 |
pMH: allelic Mantel-Haenszel fixed-effects model. pBD: Breslow-Day value.
↵* Multiple testing Bonferroni correction (× 4 analyzed haplotypes). dcSSc: diffuse cutaneous systemic sclerosis.