Table 2.

Levels of messenger RNA expression, circulating cytokines, and circulating protein biomarkers in arthralgia patients with and without progression to arthritis. Data are geometric mean (95% CI).

VariableArthritis, n = 35No Arthritis, n = 102p
Cytometric bead array assay
  IL-12p707.08 (2.04–24.55)1.91 (1.35–2.69)0.07
  TNF-α2.95 (1.54–5.62)1.45 (1.15–1.82)0.07
  IL102.29 (1.26–4.17)1.32 (1.15–1.51)0.10
  IL-62.69 (1.66–4.37)1.58 (1.38–1.82)0.05
  IL-1ß10.0 (3.16–31.6)5.50 (2.88–10.47)0.39
  IL-82.95 (1.70–5.13)2.69 (2.04–3.55)0.78
Multiplex ligation-dependent probe amplification assay
  IL-150.05 (0.04–0.05)0.05 (0.04–0.05)0.54
  NF-κB1A0.39 (0.35–0.44)0.40 (0.38–0.42)0.65
  TNF0.02 (0.02–0.02)0.02 (0.02–0.02)0.41
  IL-1ß0.11 (0.10–0.13)0.11 (0.10–0.12)0.95
  IL-1RN0.35 (0.30–0.42)0.35 (0.33–0.38)0.99
  IL-80.03 (0.03–0.04)0.03 (0.03–0.04)0.97
  MYC0.43 (0.38–0.49)0.39 (0.36–0.42)0.19
  SCYa40.09 (0.08–0.10)0.09 (0.08–0.10)0.92
  Serpin-B90.45 (0.39–0.51)0.43 (0.41–0.45)0.63
  PDGF-ß0.03 (0.03–0.04)0.03 (0.03–0.03)0.23
  PARN0.19 (0.18–0.20)0.18 (0.17–0.19)0.09
  THBS10.05 (0.04–0.05)0.04 (0.04–0.05)0.16
  LTA0.05 (0.04–0.05)0.05 (0.04–0.05)0.09
  CDKN1A0.13 (0.11–0.16)0.12 (0.11–0.13)0.27
  TNFRSF1A0.35 (0.32–0.39)0.35 (0.34–0.36)0.80
  BMI-10.11 (0.10–0.13)0.10 (0.09–0.11)0.08
  MIF0.26 (0.22–0.30)0.25 (0.23–0.27)0.73
  PDE4b0.34 (0.32–0.37)0.34 (0.32–0.35)0.84
  PTPN10.07 (0.06–0.08)0.07 (0.06–0.07)0.53
  PTP4A20.81 (0.76–0.87)0.78 (0.74–0.81)0.20
  GSTP10.05 (0.04–0.05)0.04 (0.03–0.05)0.42
Biomarkers
  Procalcitonin0.04 (0.03–0.05)0.04 (0.03–0.05)0.69
  hsCRP, mg/l2.51 (1.72–3.66)2.30 (1.82–2.90)0.71
  SPLA2, ng/ml5.79 (4.75–7.07)4.20 (3.20–5.53)0.07
Subgroup analysisEarly progressors, n = 18No arthritis, n = 102
  PARN0.20 (0.18–0.22)0.18 (0.17–0.19)0.008
  BMI-10.13 (0.11–0.15)0.10 (0.09–0.10)0.02
  • IL: interleukin; NF: nuclear factor; TNF: tumor necrosis factor; PDGF: platelet-derived growth factor; PARN: poly(A)-specific ribonuclease; THBS: thrombospondin; LTA: lymphotoxin α: CDKN: cyclin-dependent kinase inhibitor; TNFRSF: TNF receptor superfamily member; BMI-1: polycomb complex protein; MIF: macrophage migration inhibitory factor; PDE: phosphodiesterase; PTPN: tyrosine-protein phosphatase non-receptor; PTP4A2: protein tyrosine phosphatase type IVA 2; GSTP1: glutathione S-transferase P; hsCRP: high-sensitivity C-reactive protein; SPLA2: secretory phospholipase 2.