Median Larsen scores, by combinations of the 2 most significant 6q23 markers.
| Genotype Combination | rs6920220 | rs13207033 | RF+ | p* | CCP+ | p |
|---|---|---|---|---|---|---|
| 0 | 0 | 1 | 29 (180) | — | 28 (221) | — |
| 1 | 0 | 0 | 38.5 (116) | — | 38 (142) | — |
| 2 | 1 | 1 | 40 (85) | — | 34 (98) | — |
| 3 | 1 | 0 | 42 (169) | 0.007 | 37 (200) | 0.01 |
↵* For negative binomial regression with the genotype combination used as a categorical variable, adjusted for disease duration, categorized disease-modifying treatment, sex, and shared-epitope status. RF: rheumatoid factor; CCP: cyclic citrullinated peptide.