Associations between individual HLA-DRB1 shared-epitope (SE) alleles and Fok1 polymorphisms in the North American Native (NAN) population including patients and controls, and the subset of NAN with at least 1 HLA-DRB1 SE allele.
| FF (CC) | Ff (CT) | ff (TT) | ||
|---|---|---|---|---|
| All, n = 745 | ||||
| Any SE –† | 33 | 90 | 46 | chi-square 5.9, p = 0.05 |
| Any SE+ | 127 | 247 | 202 | |
| 0101– | 152 | 315 | 195 | NS |
| 0101+ | 8 | 21 | 22 | |
| 0104– | 160 | 336 | 217 | NA |
| 0104+ | 0 | 0 | 0 | |
| 0401– | 152 | 320 | 204 | NS |
| 0401+ | 8 | 16 | 13 | |
| 0404– | 93 | 205 | 127 | NS |
| 0404+ | 67 | 131 | 90 | |
| 0405– | 159 | 334 | 215 | NS |
| 0405+ | 1 | 2 | 2 | |
| 0408– | 160 | 330 | 212 | NS |
| 0408+ | 0 | 6 | 5 | |
| 0413– | 160 | 335 | 217 | NS |
| 0413+ | 0 | 1 | 0 | |
| 0416– | 160 | 336 | 217 | NA |
| 0416+ | 0 | 0 | 0 | |
| 1001– | 160 | 336 | 216 | NS |
| 1001+ | 0 | 0 | 1 | |
| 1402– | 108 | 234 | 151 | NS |
| 1402+ | 52 | 104 | 66 | |
| SE+, n = 554 | ||||
| 0101– | 119 | 225 | 159 | NS |
| 0101+ | 8 | 21 | 22 | |
| 0104– | 127 | 246 | 181 | NA |
| 0104+ | ||||
| 0401– | 119 | 230 | 168 | NS |
| 0401+ | 8 | 16 | 13 | |
| 0404– | 60 | 115 | 91 | NS |
| 0404+ | 67 | 131 | 90 | |
| 0405– | 126 | 244 | 179 | NS |
| 0405+ | 1 | 2 | 2 | |
| 0408– | 127 | 240 | 176 | NS |
| 0408+ | 0 | 6 | 5 | |
| 0413– | 127 | 245 | 181 | NS |
| 0413+ | 0 | 1 | 0 | |
| 0416– | 127 | 246 | 181 | NA |
| 0416+ | 0 | 0 | 0 | |
| 1001– | 127 | 246 | 180 | NS |
| 1001+ | 0 | 0 | 1 | |
| 1402– | 75 | 144 | 115 | NS |
| 1402+ | 52 | 102 | 66 |
↵† Specific HLA-DRB1 allele known for 713/745 tested (missing for 22 SE-positive and 10 SE-negative controls). NS: nonsignificant; NA: not available.