Median Larsen score (n) according to genotype in 6q23 risk markers, by autoantibody status. rs6920220 0 = G/G, 1 = G/A and A/A; rs5029937 0 = G/G, 1 = G/T and T/T; rs13207033 0 = G/G, 1 = G/A and A/A.
| Marker | Genotype | All | p* | RF+ | p | RF– | p | CCP+ | p | CCP– | p |
|---|---|---|---|---|---|---|---|---|---|---|---|
| rs6920220 | 0 | 25 (504) | — | 32 (307) | — | 15 (157) | — | 31 (377) | — | 14 (117) | — |
| 1 | 30 (407) | 0.14 | 40 (265) | 0.01 | 12 (115) | 0.21 | 36 (308) | 0.02 | 10 (92) | 0.62 | |
| rs5029937 | 0 | 27 (776) | — | 35.5 (492) | — | 15.5 (230) | — | 33 (584) | — | 13.5 (174) | — |
| 1 | 35 (85) | 0.33 | 36.5 (64) | 0.49 | 11 (15) | 0.92 | 35 (73) | 0.59 | 14.5 (12) | 0.98 | |
| rs13207033 | 0 | 32 (467) | — | 39 (287) | — | 14 (139) | — | 37 (345) | — | 14 (113) | — |
| 1 | 25.5 (414) | 0.12 | 32 (269) | 0.05 | 15 (121) | 0.84 | 29 (324) | 0.02 | 10 (83) | 0.84 |
↵* For negative binomial regression, adjusted for disease duration, categorized disease-modifying treatment, sex, and shared-epitope status. RF: rheumatoid factor; CCP: cyclic citrullinated peptide.