Table 6.

Patient factors associated with medication use for children with systemic arthritis (n = 246).

MedicationPatient FactorUnivariate OR (95% CI)Multivariate OR (95% CI)
MethotrexatePolyarthritis5.5 (2.8–11)4.0 (2.0–8.3)
Serositis1.9 (0.8–4.9)
Radiographic damage4.5 (1.5–13)
Disease duration, yrs1.2 (1.1–1.3)1.2 (1.0–1.3)
CyclosporinePolyarthritis1.9 (0.8–4.6)
Serositis2.3 (1.0–5.1)
Radiographic damage3.5 (1.6–7.4)3.9 (1.8–8.6)
Disease duration, yrs1.1 (1.1–1.2)
TNF inhibitorPolyarthritis3.0 (1.7–5.4)
Serositis1.7 (0.9–3.2)
Radiographic damage8.6 (4.3–18)4.7 (2.2–10)
Disease duration, yrs1.2 (1.2–1.3)1.2 (1.1–1.3)
IL-1 inhibitorPolyarthritis1.3 (0.8–2.3)
Serositis1.9 (1.0–3.5)
Radiographic damage2.6 (1.5–4.7)4.7 (2.2–10)
Disease duration, yrs1.0 (0.9–1.0)0.9 (0.8–1.0)
  • TNF: tumor necrosis factor-α; IL-1 interleukin 1.