Table 2.

Genotype frequencies for 6q23 polymorphisms in patients with rheumatoid arthritis, and according to anti-CCP status.

SNPGenotypeN (frequency)
Whole Cohort, n = 927CCP+, n = 700CCP–, n = 209p*
rs6920220G/G507 (0.55)379 (0.55)117 (0.56)
G/A354 (0.39)266 (0.39)80 (0.38)
A/A55 (0.06)43 (0.06)12 (0.06)0.95
rs13207033G/G469 (0.53)347 (0.52)113 (0.58)
G/A359 (0.41)281 (0.42)71 (0.36)
A/A58 (0.06)44 (0.06)12 (0.06)0.32
rs5029937G/G776 (0.90)587 (0.89)174 (0.94)
G/T82 (0.10)70 (0.11)12 (0.06)
T/T3 (0.00)3 (0.00)0 (0.00)0.20
  • * Genotype frequencies for each SNP were compared according to anti-CCP antibody status using the chi-square test for rs6920220 and rs13207033, and Fisher’s exact test for rs5029937. There was also no significant difference in genotype frequencies. SNP: single-nucleotide polymorphism; CCP: cyclic citrullinated peptide.