Table 2.

Multiple regression analysis was used to test any influence of vasculitis/controls, age, and cytomegalovirus (CMV) on the proportion (%) of different T cell subpopulations in the whole group of patients and controls. p < 0.05 was considered significant (indicated in bold type). As in univariate analyses, latent CMV infection (but not vasculitis) was associated with CD8+CD28– and CD4+CD28– T cells, and also with CD8+CD57+ and CD4+CD57+ T cells. In contrast, the proportions of T cells expressing CD56 did not differ across groups. Using the variable “active vasculitis versus remission” instead of “vasculitis versus controls” did not change the results (data not shown).

Proportion (%) of CD8+Age, pCMV+ vs –, pVasculitis vs Controls, pProportion (%) of CD4+Age, pCMV+ vs –, pVasculitis vs Controls, p
CD8+CD56+ % of CD80.5280.3030.763CD4+CD56+ % of CD40.5560.2570.736
CD8+CD57+ % of CD80.0050.0040.746CD4+CD57+ % of CD40.0100.0020.304
CD8+CD28– % of CD80.0230.0030.648CD4+CD28– % of CD40.0470.0050.669