Associations in Swedish and Spanish rheumatoid arthritis cohorts that were negative for autoantibodies to citrullinated proteins/peptides.
| Swedish EIRA Study (690 cases, 1076 controls) | Spanish Study (359 cases, 1090 controls) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP (gene/loci) | Minor Allele | MAF, Cases | MAF, Controls | Uncorrected p | Bonnferroni-corrected p | Minor Allele | MAF, Cases | MAF, Controls | Uncorrected p | Bonferroni-corrected p | Metaanalysis OR (95% CI)a |
| rs12693591 (STAT1) | A | 0.154 | 0.114 | 0.0007 | 0.0196 | A | 0.15 | 0.15 | NS | 1.98 (1.12–3.53)b | |
| rs10173099 (STAT1) | A | 0.329 | 0.294 | 0.0266 | NS | A | 0.36 | 0.36 | NS | NS | |
| rs6751855 | G | 0.482 | 0.433 | 0.0041 | NS | Gd | 0.52d | 0.52d | NS | 1.24 (1.04–1.47)c | |
| rs7574865 (STAT4) | T | 0.262 | 0.228 | 0.0107 | NS | T | 0.27 | 0.21 | 0.00144 | 0.01296 | 1.59 (1.20–2.10)b |
| rs3024935 (STAT4) | A | 0.087 | 0.060 | 0.0025 | NS | A | 0.07 | 0.09 | NS | NS | |
| rs11889341 (STAT4) | T | 0.256 | 0.225 | 0.0237 | NS | NA | NA | NA | NA | NA | |
| rs8179673 (STAT4) | C | 0.262 | 0.230 | 0.0158 | NS | NA | NA | NA | NA | NA | |
| rs10181656 (STAT4) | G | 0.261 | 0.226 | 0.0113 | NS | NA | NA | NA | NA | NA | |
| rs9891119 (STAT3) | C | 0.390 | 0.334 | 0.0007 | 0.0196 | C | 0.38 | 0.37 | NS | 1.29 (1.05–1.60)b | |
| rs8069645 (STAT3) | G | 0.291 | 0.243 | 0.0015 | 0.042 | G | 0.29 | 0.28 | NS | NS | |
| rs744166 (STAT3) | G | 0.467 | 0.411 | 0.0011 | 0.0308 | G | 0.43 | 0.42 | NS | 1.35 (1.12–1.63)b | |
| rs8074524 (STAT3) | A | 0.202 | 0.163 | 0.0034 | NS | A | 0.20 | 0.22 | NS | NS | |
| rs4103200 (STAT3) | C | 0.283 | 0.246 | 0.0080 | NS | NA | NA | NA | NA | NA | |
| rs9912773 (STAT3) | G | 0.271 | 0.229 | 0.0023 | NS | NA | NA | NA | NA | NA | |
| rs17405722 | A | 0.099 | 0.089 | NS | NS | NA | NA | NA | NA | NA | |
↵a By Mantel-Haenszel method (fixed-effects model).
↵b Recessive model.
↵c Dominant model.
↵d Corresponds to risk allele G in the EIRA study. SNP shown in bold type are those investigated in the Spanish cohort. EIRA: Swedish Epidemiological Investigation of Rheumatoid Arthritis; SNP: single-nucleotide polymorphisms; MAF: minor allele frequency; NS: not significant; NA: not available.