Table 4.

PASS according to change in treatment indicated by physician. Values are median (interquartile range, 25th–75th percentile) unless otherwise indicated.

VariableNo Change in Treatment Indicated by Physician, n = 142Change in Treatment Indicated by Physician, n = 48
PASS AffirmativePASS NegativePASS AffirmativePASS Negativep
Number (%)125 (88)17 (12)21 (44)27 (56)
Physician global assessment (100-mm VAS)20 (10–30)30 (10–40)50 (40–70)60 (50–80)< 0.001
Patients’ global assessment (100-mm VAS)30 (10–50)50 (40–60)50 (40–70)70 (60–80)< 0.001
Total pain (100-mm VAS)30 (10–50)50 (30–60)60 (40–90)70 (60–80)< 0.001
Fatigue (100-mm VAS)25 (10–40)50 (35–70)60 (40–80)50 (30–70)< 0.001
BASDAI (0–10 scale)2.4 (1.1–3.9)4.9 (4.3–5.4)5 (3.9–6.2)6 (4.9–7)< 0.001
BASDAI > 4; n (%)29 (24)13 (81)14 (67)26 (96)< 0.001
BASFI (0–10 scale)2.4 (0.9–4.8)4.2 (3.8–6.7)5.6 (2.2–7.4)5.5 (2.9–7.5)< 0.001
ASQOL (0–18 scale)4 (1–8)11 (4–14)10 (6–12)10 (8–13)< 0.001
HADS anxiety (0–21)6 (4–9)10 (6–14)8 (7–12)10 (7–15)< 0.001
HADS depression (0–21)3 (1–6)8 (6–13)5 (2–7)8 (4–9)< 0.001
Serum C-reactive protein, mg/dl0.3 (0.2–0.8)0.6 (0.3–1.4)0.7 (0.4–1.5)1.3 (0.4–3.1)< 0.001
ASDAS-CRP, mean ± SD2.0 ± 0.92.9 ± 0.73.1 ± 0.83.8 ± 0.9< 0.001
  • PASS: patient-acceptable symptom state; VAS: visual analog scale; BASDAI: Bath Ankylosing Spondylitis Disease Activity Index; BASFI: Bath Ankylosing Spondylitis Functional Index; ASQOL: Ankylosing Spondylitis Quality of Life questionnaire; ASDAS-CRP: Ankylosing Spondylitis Disease Activity Score, based on C-reactive protein; HADS: Hospital Anxiety Depression Scale.