Logistic regression analysis of associations between PAD14 rs2240340 G/A, PAD14 rs874881 C/G, MBD4 rs140693 G/A, and MBD4 rs2005618 T/C polymorphisms and risk of rheumatoid arthritis.
| Genotype | Cases*, n (%) n = 329 | Controls, n (%) n = 697 | OR (95% CI) | p |
|---|---|---|---|---|
| PAD14 rs2240340 G/A | ||||
| GG | 102 (31.5) | 244 (35.1) | 1.00 | — |
| GA | 152 (46.9) | 339 (48.8) | 1.07 (0.80–1.45) | 0.647 |
| AA | 70 (21.6) | 112 (16.1) | 1.50 (1.03–2.18) | 0.037 |
| GG + GA | 254 (78.4) | 583 (83.9) | 1.00 | — |
| AA | 70 (21.6) | 112 (16.1) | 1.44 (1.03–2.00) | 0.034 |
| A allele | (45.1) | (40.5) | ||
| PAD14 rs874881 C/G | ||||
| CC | 96 (30.8) | 243 (35.0) | 1.00 | — |
| CG | 145 (46.5) | 338 (48.7) | 1.09 (0.80–1.48) | 0.598 |
| GG | 71 (22.8) | 113 (16.3) | 1.59 (1.09–2.32) | 0.017 |
| CC + CG | 241 (77.2) | 581 (83.7) | 1.00 | — |
| GG | 71 (22.8) | 113 (16.3) | 1.52 (1.09–2.11) | 0.014 |
| G allele | (46.0) | (40.6) | ||
| MBD4 rs140693 G/A | ||||
| GG | 119 (37.3) | 260 (37.4) | 1.00 | — |
| GA | 154 (48.3) | 326 (46.8) | 1.03 (0.77–1.38) | 0.831 |
| AA | 46 (14.4) | 110 (15.8) | 0.91 (0.61–1.37) | 0.664 |
| GG + GA | 273 (85.6) | 586 (84.2) | 1.00 | — |
| AA | 46 (14.4) | 110 (15.8) | 0.90 (0.62–1.30) | 0.570 |
| A allele | (38.6) | (39.2) | ||
| MBD4 rs2005618 T/C | ||||
| TT | 93 (28.7) | 185 (26.6) | 1.00 | — |
| TC | 162 (50.0) | 356 (51.1) | 0.91 (0.66–1.24) | 0.530 |
| CC | 69 (21.3) | 155 (22.3) | 0.89 (0.61–1.29) | 0.528 |
| TT + TC | 255 (78.7) | 541 (77.7) | 1.00 | — |
| CC | 69 (21.3) | 155 (22.3) | 0.94 (0.69–1.30) | 0.727 |
| C allele | (46.3) | (47.8) |
↵* Genotyping was successful in 324 cases and 695 controls for PAD14 rs2240340 G/A; 312 cases and 694 controls for PAD14 rs874881 C/G; 319 cases and 696 controls for MBD4 rs140693 G/A; 324 cases and 696 controls for MBD4 rs2005618 T/C.