Stepwise multiple linear regression analysis to identify independent clinical variables associated with bone mineral density.
| Variables | ß | Standard Error | F Value | p |
|---|---|---|---|---|
| Femoral neck BMD | ||||
| Mitochondrial DNA copy number* | 0.156 | 0.035 | 21.21 | < 0.001 |
| Adiponectin* | −0.047 | 0.013 | 13.48 | < 0.001 |
| Osteocalcin | −0.004 | 0.002 | 6.88 | 0.01 |
| HDL-cholesterol | 0.001 | < 0.0001 | 3.38 | 0.07 |
| Lumbar BMD | ||||
| Waist-hip ratio | 0.491 | 0.27 | 3.28 | 0.07 |
| Osteocalcin | −0.006 | 0.003 | 2.72 | 0.10 |
All variables left in the model are significant at the 0.15 level; no other variable met the 0.15 level for entry into the model. R2 for femoral neck BMD and lumbar were 0.26 and 0.04, respectively. Mitochondrial DNA copy number was independent variable and regression coefficients (ß) were adjusted for age, BMI, waist circumference, systolic and diastolic blood presure, HOMA-IR, hsCRP, homocysteine, total cholesterol, LDL-cholesterol, triglyceride, 25-OH vitamin D, and regular exercise. BMI: body mass index; BMD: bone mineral density; HDL: high-density lipoprotein; HOMA-IR: homeostasis model assessment of insulin resistance; hsCRP: high-sensitivity C-reactive protein; LDL: low-density lipoprotein.
↵* Log-transformation to improve distribution.