Table 4.

Hazard ratio (HR) of death according to treatment status of biologics.

HR (95% CI)p
Total subjects
  Sex- and age-adjusted0.26 (0.11, 0.60)0.002
  Multivariable-adjusted, model 10.18 (0.05, 0.59)0.005
  Multivariable-adjusted, model 20.28 (0.07, 1.16)0.080
Subjects with Ccr ≥ 30 ml/min/1.73 m2*
  Sex- and age-adjusted0.13 (0.03, 0.69)0.016
  Multivariable-adjusted, model 10.18 (0.03, 1.28)0.088
  Multivariable-adjusted, model 20.21 (0.03, 1.48)0.116
  • Multivariable model adjusted for sex, age, hematocrit (Ht), albumin (Alb), creatinine (Cr), and C-reactive protein (CRP). Numbers of valid cases in the biologic and nonbiologic groups were 53 and 80 for the sex- and age-adjusted model; 36 and 75 for multivariable model 1 adjusted for sex, age, Ht, Alb, Cr, and CRP; and 36 and 68 for multivarable model 2 adjusted for sex, age, Ht, Alb, creatinine clearance (Ccr), and CRP, respectively.

  • * Ccr < 30 ml/min/1.73 m2 was excluded from the analysis. Multivariable model adjusted for sex, age, Ht, Alb, Cr, Ccr and CRP. Numbers of valid cases in biologic and nonbiologic groups were 31 and 47 for the sex- and age-adjusted model; 31 and 46 for multivariable model 1 adjusted for sex, age, Ht, Alb, Cr, and CRP; and 31 and 46 for multivariable model 2 adjusted for sex, Ht, Alb, Ccr, and CRP, respectively.