Hazard ratios (HR) for incident cardiovascular disease in the 105 patients with RA (1 case excluded when indicated), univariate and age-adjusted Cox regression analyses.
| Variables | HR (95% CI) | p | Age-adjusted HR (95% CI) | p |
|---|---|---|---|---|
| Age at RA onset | 1.06 (1.01–1.11) | 0.016 | – | |
| ΔoxLDL (60–0 mo)† | 1.03 (1.01–1.06) | 0.008 | 1.03 (1.0–1.06) | 0.035 |
| ΔDAS28 (0–12 mo) | 0.69 (0.49–0.98) | 0.041 | 0.68 (0.5–0.97) | 0.035 |
| ΔHAQ (0–12 mo) | 0.36 (0.15–0.86) | 0.020 | 0.35 (0.15–0.82) | 0.016 |
| ΔHAQ (0–60 mo)† | 0.29 (0.15–0.58) | 0.000 | 0.26 (0.13–0.55) | 0.000 |
| ΔVAS pain (0–12 mo) | 0.97 (0.95–0.99) | 0.004 | 0.97 (0.95–0.99) | 0.005 |
| HAQ at 5 yrs† | 2.53 (1.31–4.87) | 0.006 | 2.54 (1.31–4.92) | 0.006 |
| MTX use | 0.32 (0.12–0.87) | 0.025 | 0.34 (0.12–0.91) | 0.033 |
| Bilateral carotid plaque† | 3.34 (1.21–9.22) | 0.020 | 2.16 (0.66–7.05) | 0.20 |
↵† Analyses where 1 case was excluded due to CVD occurrence about 2 years after disease onset. oxLDL: oxidized low-density lipoprotein; DAS28: Disease Activity Score in 28 joints; HAQ: Health Assessment Questionnaire; VAS: visual analog scale; MTX: methotrexate; cIMT: carotid intima-media thickness.