JA-CASS cutoff values for parent-reported and physician-reported outcome measures and acute-phase reactant levels as defined by the 75th percentile of the cumulative distribution of each specific measure or ROC curve analysis, percentage of patients with scores below these cutoffs but still reported by their parents not being in JA-CASS (i.e., false positives), and sensitivity and specificity of ROC cutoffs.
| Variable and Range | 75th Percentile Cutoff | False Positives, n (%) | ROC Cutoff | Sensitivity, % | Specificity, % |
|---|---|---|---|---|---|
| Child well-being VAS score, 0–10 | 1 | 30 (14.5) | 1 | 75.6 | 72.0 |
| Child pain VAS score, 0–10 | 1 | 33 (15.3) | 1.5 | 82.1 | 66.3 |
| Child disease activity VAS score, 0–10 | 1 | 29 (14.4) | 0.5 | 70.7 | 81.7 |
| Child JAFS total score, 0–30 | 1 | 54 (21.9) | 0 | 66.9 | 65.4 |
| Child PRQL total score, 0–30 | 4 | 49 (20.6) | 2 | 60.2 | 76.6 |
| Child PRQL-PhH score, 0–15 | 2 | 42 (17.9) | 1 | 67.4 | 75.7 |
| Child PRQL-PsH score, 0–15 | 2 | 70 (26.6) | 0 | 41.5 | 75.7 |
| PGA VAS, 0–10 | 1 | 23 (13.6) | 1.5 | 64.4 | 78.5 |
| No. disease-active joints, 0–73 | 1 | 30 (16.9) | 0 | 63.1 | 85.1 |
| No. swollen joints, 0–68 | 1 | 36 (18.8) | 0 | 70.1 | 77.0 |
| No. tender joints, 0–73 | 1 | 30 (16.9) | 0 | 67.4 | 81.1 |
| No. restricted joints, 0–71 | 1 | 40 (22.1) | 0 | 58.8 | 71.6 |
| ESR, mm/h, 20–140 | 20 | 32 (19.9) | 19 | 73.8 | 61.8 |
| CRP, mg/dl, < 0.46–infinity* | 0.3 | 41 (22.2) | 0.3 | 85.2 | 47.4 |
↵* All values below 0.46 mg/dl were converted to 0.3 mg/dl. JA-CASS: child acceptable symptom state in juvenile arthritis; ROC: receiver-operating characteristic; VAS: visual analog scale; JAFS: Juvenile Arthritis Functionality Scale; PRQL: Paediatric Rheumatology Quality of Life Scale; PhH: physical health; PsH: psychosocial health; PGA: physician global assessment; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein.