Feature | cNPSLE, n = 34 | Non-NPSLE, n = 44 | SLE-surgical, n = 16 | Neuro-primary, n = 4 | Non-AU, n = 25 | p |
---|---|---|---|---|---|---|
Age, yrs | 31.4 ± 12.2 | 30.8 ± 12.6 | 37.8 ± 9.8 | 24.3 ± 10.5 | 37.5 ± 15.3 | 0.46 |
Female/male | 29/5 | 14/2 | 40/4 | 4/0 | 19/6 | |
SLE duration, yrs | 3.6 ± 4.5 | 8.8 ± 7.2 | 3.8 ± 5.7 | — | — | 0.05 |
SLEDAI-2K | 15.3 ± 8.15 | 12.4 ± 8.2 | 3.8 ± 1.5 | — | — | < 0.001 |
Serum IFN-α, median pg/ml (range) | 76.4 (3.2–1074.4) | 101.2 (2.3–3641.5) | 74 (3.2–2644.9) | 134.4 (91.9–173.2) | 27 (2.3–250.1) | < 0.001 |
CSF IFN-α, median pg/ml (range) | 28.3 (3.2–193.9) | — | 15 (3.2–52.3) | 9.9 (4.9–67.8) | 17.4 (32–54.4) | < 0.001 |
Non-NPSLE: lupus patients without current or past NP manifestations; SLE-surgical: lupus patients who underwent elective surgery; neuro-primary: patients with primary neurologic diseases; non-AU: patients without autoimmune diseases; SLEDAI-2K: Systemic Lupus Erythematosus Disease Activity Index 2000 update.