Demographic data of the patients (n = 26) at the time of decision for autologous stem cell transplant and outcome.
| Characteristic | |
|---|---|
| Median age, yrs (range) | 39 (19–65) |
| Median disease duration, yrs (range) | 2.25 (1–17) |
| No. women/men | 18/8 |
| Scl-70 antibody | 19 with; 7 without |
| Baseline modified Rodnan skin score (mRSS) | 18.2 (2–32) |
| Baseline CRP, mg/dl (range) | 3.5 (0.1–18.6) |
| Baseline ESR, mm/h (range) | 37.3 (6–91) |
| Baseline DLCO, % expected (range) | 58 (32–104) |
| Median followup, yrs (range) | 4.4 (1.1–12.2) |
| Outcome in all patients (n = 26) | |
| 100-day transplant-related mortality*, % | 4 |
| Overall survival probability, first 3 yrs*, % | 74 |
| Progression-free survival probability, first 3 yrs*, % | 53 |
| Outcome in patients successfully transplanted (n = 23) | |
| Early response (> 25% reduction in mRSS at Month 6), % (n) | 78 (18) |
| Late response, % (n) | 14 (3) |
| Overall response rate, % (n) | 91 (21) |
| Relapse rate, % (n) | 30.4 (7) |
↵* Estimated from Kaplan-Meier plot. CRP: C-reactive protein; ESR: erythrocyte sedimentation rate.