Table 1.

Recently identified biomarkers for psoriatic disease.

BiomarkerScreening*Disease ActivityTreatment ResponseRadiographic Change
Peripheral blood/serum/plasma
  Bone alkaline phosphatase
  C-reactive protein
  Cartilage oligomeric matrix protein
  Ratio of C-propeptide of type II collagen to collagen fragment neoepitopes Col2–3/4 (long mono)
  Interleukin 6 (IL-6)
  Matrix metalloproteinase-3
  Melanoma inhibitory activity
  Macrophage-colony stimulating factor
  Circulating osteoclast precursors
  Receptor activator of nuclear factor kappa-B ligand
Synovial fluid
  Chemokine (C-C motif) ligand 3
  IL-1 receptor antagonist
Synovial tissue
  CD3-positive cells
  IL-17 pathway genes
  • * Screening indicates screening psoriasis patients for PsA.

  • Radiographic change indicates both erosions and new bone formation.