Table 6.

Predictors for ISN/RPS class III or IV lupus nephritis.

Patient GroupSensitivity, %Specificity, %PPV, %NPV, %OR (95% CI)p
Patients of the overt subset, n = 109
  Proteinuria, ≥ 1120 mg/day617481524.6 (1.9–11.0)0.0003
  eGFR, ≤ 63.8 ml/min/1.73 m2568083504.9 (2.0–12.1)0.0004
  Anti-dsDNA, ≥ 75 IU/ml478787486.1 (2.2–17.3)0.0003
Patients of the silent subset, n = 86
  Anti-dsDNA, ≥ 40 IU/ml855324956.3 (1.3–30.5)0.015
  C3 ≤ 55 mg/dl855824957.5 (1.5–36.1)0.0063
  Anti-dsDNA, ≥ 40 IU/ml and C3 ≤ 55 mg/dl777333958.8 (2.2–35.4)0.0011
  • ISN/RPS: International Society of Nephrology/Renal Pathology Society; PPV: positive predictive value; NPV: negative predictive value; eGFR: estimated glomerular filtration rate.