Comparison of active and chronic lesions in ISN/RPS class III and class IV between patients with and without clinical renal involvement.
| Lesion Type | Overt Subset, n = 70 | Silent Subset, n = 13 | p |
|---|---|---|---|
| Active lesions, n (%) | |||
| Endocapillary proliferation | 66 (94) | 11 (85) | 0.24 |
| Wire loops | 19 (27) | 6 (46) | 0.17 |
| Cellular/fibrocellular crescents | 29 (41) | 0 (0) | 0.003 |
| Fibrinoid necrosis | 5 (7) | 1 (8) | 1 |
| Rupture of GBM | 9 (13) | 0 (0) | 0.34 |
| Karyorrhexis | 6 (9) | 2 (15) | 0.60 |
| Chronic lesions, n (%) | |||
| Global sclerosis | 30 (43) | 4 (30) | 0.54 |
| Fibrous crescents/adhesions | 13 (19) | 1 (8) | 0.44 |
ISN/RPS: International Society of Nephrology/Renal Pathology Society; overt subset: patients with clinical renal involvement; silent subset: patients without clinical renal involvement; GBM: glomerular basement membrane.