Baseline characteristics of the early rheumatoid arthritis cohort (current smokers vs nonsmokers). Results are expressed in mean values ± SD or percentages, unless otherwise indicated.
| Characteristics | All Patients, n = 156 | Current Smokers, n = 47 | Nonsmokers, n = 90 | p |
|---|---|---|---|---|
| Women, n (%) | 130 (83.3) | 30 (63.8) | 86 (95.6) | < 0.001 |
| Age, yrs | 54.4 ± 14.9 | 48.3 ± 13.2 | 57.3 ± 15.1 | 0.001 |
| Disease duration, mo | 9.7 ± 6.6 | 8.4 ± 5.1 | 10.3 ± 6.8 | 0.088 |
| VAS pain, mm | 49 ± 23.3 | 50.6 ± 22.9 | 49.8 ± 24.1 | 0.864 |
| Patient global assessment, mm | 58.4 ± 15.9 | 59.1 ± 18.5 | 58.2 ± 14 | 0.755 |
| Physician global assessment, mm | 56 ± 14 | 59.3 ± 14.5 | 54.4 ± 12.3 | 0.056 |
| 28 Tender joint count | 9.9 ± 6 | 9.5 ± 6.4 | 10.4 ± 5.7 | 0.856 |
| 28 Swollen joint count | 7.6 ± 4.3 | 7.9 ± 4.5 | 7.6 ± 4 | 0.677 |
| DAS28 | 5.6 ± 0.9 | 5.6 ± 1 | 5.7 ± 0.9 | 0.398 |
| Modified HAQ | 0.9 ± 0.6 | 0.97 ± 0.6 | 0.9 ± 0.6 | 0.731 |
| ESR, mm/h | 40.7 ± 26.4 | 36 ± 22.6 | 40.7 ± 25 | 0.285 |
| CRP, mg/dl | 2.8 ± 3 | 2.6 ± 2.6 | 2.8 ± 3.2 | 0.682 |
| Larsen score | 1.9 ± 6.9 | 1.8 ± 6.3 | 1.2 ± 2.7 | 0.447 |
| Erosion joint count | 0.4 ± 1.3 | 0.4 ± 0.9 | 0.3 ± 0.8 | 0.400 |
| Larsen score ≥ 1, n (%) | 48 (30.8) | 14 (29.8) | 29 (32.2) | 0.771 |
| Erosion joint count ≥ 1, n (%) | 29 (18.6) | 11 (23.4) | 14 (15.6) | 0.259 |
| RF-positive, n (%) | 119 (76.3) | 40 (85.1) | 67 (74.4) | 0.152 |
| RF-positive, IU/l | 233.1 ± 487.2 | 378.7 ± 782.6 | 138.3 ± 174.9 | 0.043 |
| ACPA2-positive, % | 112/148 (75.7) | 36/43 (83.7) | 65/88 (73.9) | 0.207 |
| ACPA2-positive, IU/l | 767.5 ± 615.8 | 774.1 ± 616.7 | 772.9 ± 619.5 | 0.992 |
| CFFCP1-positive, % | 73.9 | 76.5 | 75 | 0.872 |
| CFFCP1-positive, ODU | 1.5 ± 1 | 1.6 ± 1 | 1.4 ± 1 | 0.388 |
| SE | 72.7 | 92.1 | 65.3 | 0.002 |
| SE homozygosity, % | 19.5 | 29 | 14.7 | 0.04 |
| HLA-DRB*04, % | 44.6 | 68.4 | 32.5 | 0.004 |
VAS: visual analog scale; DAS28: 28-joint Disease Activity Score; HAQ: Health Assessment Questionnaire; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; RF: rheumatoid factor; ACPA: anticitrullinated protein antibodies; CFFCP: anticyclic citrullinated fibrin-filaggrin autoantibodies; ODU: optical density units; SE: shared epitope.