Table 2.

Phenotype of peripheral blood CD4+ T cells in patients with rheumatoid arthritis (RA) and in healthy controls. Data are percentage of CD4+ T cells; median (range). Within-group comparisons were made using the Mann-Whitney U test.

Study Participants	CD4+CD25–	CD4+CD25+	CD4+CD25+CD127^low/–	CD4+CD25^highCD127^low/–
Healthy controls, n = 14	84.7 (72.4–87.2)	15.3 (12.8–27.6)	3.63 (2.34–7.54)	3.76 (2.11–9.80)
DMARD-naive RA group, n = 13	78.3 (63.9–88.3)	21.7 (11.7–36.1)	3.12 (1.72–5.73)	2.23^** (0.57–5.18)
Active RA group, n = 19	79.9 (63.9–87.2)	20.1 (12.8–36.1)	2.76^* (1.25–5.31)	1.35^***^# (0.41–2.21)
Remission group, n = 16	80.6 (66.6–90.1)	19.4 (9.9–33.4)	3.35 (2.13–7.21)	2.98^$ (1.34–4.89)

↵* p < 0.05,
↵** p < 0.01,
↵*** p < 0.0001 vs HC,
↵# p < 0.01 vs DMARD-naive RA group,
↵$ p < 0.0001 vs active RA group. DMARD: disease-modifying antirheumatic drugs.