Characteristics of patients with rheumatoid arthritis (n = 1270) and controls (n = 186) at enrollment.
| Characteristics | Mean (SD) or % | |
|---|---|---|
| RA, n = 1270 | Controls, n = 186 | |
| Demographic | ||
| Age at enrollment, yrs (SD) | 63.6 (11.4) | 56.5 (12.5) |
| Male, % | 90.5 | 67.4 |
| Race, % | ||
| White | 77.6 | 93.0 |
| African American | 16.5 | |
| Other | 5.8 | |
| ≥ High school education, % | 84.0 | |
| Smoking status, % | ||
| Never | 20.3 | |
| Former | 52.0 | |
| Current | 27.7 | |
| Body mass index, kg/m2 (SD) | 28.3 (5.6) | |
| Comorbidity count (0–9) (SD) | 3.2 (1.8) | |
| RA-related measures at enrollment | ||
| Disease duration at enrollment, yrs | 12.2 (11.5) | |
| HLA-DRB1 SE-positive, % | 71.7 | |
| ACPA-positive, % | 75.6 | |
| Rheumatoid factor-positive, % | 80.5 | |
| Subcutaneous nodules, % | 36.1 | |
| hsCRP, mg/l | 13.0 (20.1) | |
| hsCRP ≥ 3 mg/l, % | 69.5 | |
| ESR, mm/h | 26.0 (22.2) | |
| Tender joint count (0 to 28) | 5.0 (6.7) | |
| Swollen joint count (0 to 28) | 4.1 (5.4) | |
| Pain (0 to 10) | 4.5 (2.9) | |
| Physician global (0 to 100 mm) | 36.4 (22.8) | |
| Patient global (0 to 100 mm) | 41.1 (25.6) | |
| Multidimensional HAQ (0 to 3) | 0.93 (0.60) | |
| DAS28 category, % | ||
| < 2.6 (remission) | 22.9 | |
| ≥ 2.6 and < 3.2 (low activity) | 14.6 | |
| ≥ 3.2 and < 5.1 (moderate activity) | 40.8 | |
| ≥ 5.1 (high activity) | 21.8 | |
| RAPID-3 score | 2.6 (1.4) | |
| Prednisone use | 43.2 | |
| Methotrexate use | 55.6 | |
| Anti-TNF-α use | 29.4 | |
| CD14 genotypes | ||
| rs2569190 (CD14/–260), % | ||
| GG | 30.0 | |
| AG | 49.4 | |
| AA | 20.7 | |
| rs5744455 (CD14/–651), % | ||
| CC | 64.1 | |
| CT | 31.5 | |
| TT | 4.5 | |
| rs2915863 (CD14/–1720), % | ||
| TT | 39.7 | |
| CT | 45.2 | |
| CC | 15.1 | |
| rs2569193 (CD14/–2838), % | ||
| GG | 54.5 | |
| AG | 38.4 | |
| AA | 7.2 | |
SE: shared epitope; ACPA: anticitrullinated protein antibody; hsCRP: high sensitivity C-reactive protein; ESR: erythrocyte sedimentation rate; MD-HAQ: Multidimensional Health Assessment Questionnaire; DAS: Disease Activity Score; RAPID: Routine Assessment of Patient Index Data; TNF: tumor necrosis factor.