Table 3.

Association between pack-year categories and disease measures. Values are median (interquartile range).

Pack-Years
0, n = 3081–15, n = 11316–30, n = 92> 30 n = 62p (trend)*
BASDAI4.0 (2.0–6.0)4.0 (2.0–7.0)5.0 (3.0–6.0)6.0 (4.0–8.0)0.01
BASFI4.0 (2.0–6.0)5.0 (2.0–7.0)5.0 (3.0–8.0)7.0 (4.0–9.0)< 0.0001
Pain NRS4.0 (2.0–7.0)5.0 (2.2–7.0)5.0 (3.0–7.0)6.0 (4.0–8.0)0.008
ASQoL6.0 (2.0–12.0)7.0 (2.0–12.0)9.2 (3.0–13.0)12.0 (5.0–15.0)0.001
EASi-QoL
  PF7.0 (3.0–11.0)7.0 (4.0–12.5)8.0 (4.0–15.0)13.0 (6.0–17.5)< 0.0001
  DA7.0 (4.0–11.0)7.0 (4.2–11.0)8.0 (5.0–11.7)10.0 (8.0–13.0)< 0.0001
  EW4.0 (2.0–9.0)5.0 (2.0–9.0)6.0 (2.0–10.5)9.0 (2.7–14.0)< 0.0001
  SP5.0 (2.0–10.0)6.0 (3.0–11.0)7.0 (3.0–12.0)9.5 (5.0–15.0)< 0.0001
  • * Jonckheere-Terpstra test. BASDAI: Bath Ankylosing Spondylitis Disease Activity Index; BASFI: Bath AS Functional Index; NRS: numerical rating scale; ASQoL: AS Quality of Life; EASi-QoL: Evaluation of AS Quality of Life. PF: physical function; DA: disease activity; EW: emotional well-being; SP: social participation.