Table 3.

Relationship between measures of renal function and cardiovascular risk factors, inflammation, and coronary calcium score in patients with rheumatoid arthritis.

	Cystatin C			Creatinine			MDRD-eGFR
Factor	Rho^†	p^*	Adjusted p^**	Rho^†	p^*	Adjusted p^**	Rho^†	p^*	Adjusted p^**
Age	0.442	< 0.001	—	0.182	0.02	—	−0.329	< 0.001	—
Body mass index	−0.096	0.22	0.36	−0.134	0.09	0.58	0.120	0.12	0.56
Systolic blood pressure	0.198	0.01	0.89	0.095	0.22	0.30	−0.154	0.05	0.32
Diastolic blood pressure	0.116	0.14	0.66	0.113	0.15	0.80	−0.019	0.81	0.95
HDL cholesterol	−0.149	0.06	0.02	−0.072	0.36	0.87	−0.032	0.68	0.95
LDL cholesterol	−0.042	0.59	0.36	−0.136	0.08	0.12	0.112	0.15	0.20
Homocysteine	0.493	< 0.001	< 0.001	0.355	< 0.001	0.004	−0.238	0.002	0.02
Framingham score	0.438	< 0.001	0.02	0.038	0.63	0.63	−0.237	0.002	0.57
Disease duration	0.149	0.06	0.83	−0.082	0.29	0.06	−0.014	0.86	0.09
DAS28 Index	0.193	0.01	0.006	−0.074	0.35	0.40	0.014	0.85	0.37
ESR	0.256	0.001	< 0.001	−0.021	0.79	0.88	−0.035	0.65	0.50
CRP	0.200	0.01	0.01	−0.085	0.27	0.46	0.045	0.57	0.43
TNF-α	0.198	0.01	0.11	0.021	0.79	0.31	−0.023	0.77	0.25
IL-6	0.104	0.19	0.32	−0.057	0.47	0.41	0.037	0.64	0.41
Coronary calcium score	0.323	< 0.001	0.44	0.202	0.01	0.47	−0.172	0.03	0.78

↵† Univariate Spearman correlation coefficient (n = 167).
↵* Spearman’s correlation test.
↵** Multivariable linear regression was used for adjustment of age, race, and sex; except for coronary calcium score, which used proportional odds logistic regression with additional adjustment for Framingham risk score. MDRD-eGFR: Modified Diet in Renal Disease formula estimated glomerular filtration rate; HDL: high-density lipoprotein; LDL: low-density lipoprotein; DAS28: 28-joint Disease Activity Score; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; TNF-α: tumor necrosis factor-α; IL-6 interleukin 6.