Table 1.

Patient and disease characteristics (n = 22). All data are n (%) unless otherwise indicated.

CharacteristicsN (%)
Demographic characteristics
  Male17 (77)
  Median age at onset of arthritis, yrs (IQR)10.4 (0.4–12.0)
  Median disease duration before start of anti-TNF, yrs (IQR)3.1 (1.1–5.9)
Disease characteristics
  Presence of HLA-B27 antigen15 (68)
  ≤ 4 active joints at start of anti-TNF7 (32)
  > 4 active joints at start of anti-TNF15 (68)
Enthesitis17 (77)
    In Achilles tendon13 (76)
  History of sacroiliac joint tenderness and/or inflammatory lumbosacral pain12 (55)
  Onset of arthritis in male > 6 yrs old16 (73)
  Anterior uveitis0 (0)
  Family history of HLA-B27-related disease12 (55)
Medication history before start of anti-TNF therapy
  NSAID21 (96)
  Systemic glucocorticoids8 (36)
  Intraarticular glucocorticoids4 (18)
  Methotrexate21 (96)
  Sulfasalazine17 (77)
  Leflunomide2 (9)
  Azathioprine1 (5)
Concomitant medications at start of anti-TNF therapy
  NSAID19 (86)
  Systemic glucocorticoids3 (14)
  Methotrexate17 (77)
  Sulfasalazine2 (9)
  Leflunomide0 (0)
  Azathioprine0 (0)
  • IQR: interquartile range; TNF: tumor necrosis factor; NSAID: nonsteroidal antiinflammatory drugs.