Clinical characteristics of new TB infections occurring in patients with ankylosing spondylitis.
| Patient | Age, yrs | TNF Blocker | Disease Duration, yrs | Peripheral Arthritis | HLA-B27 | DM | DMARD | Mean Steroid, mg/day | History of TB | Old TB on CXR | TST | Prophylaxis | Interval to Active TB*, mo | Diagnosis Method | TB Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 32 F | — | 25 | + | + | — | MTX + SSZ | 2.5 | — | — | ND | ND | 228 | AFB (+) CXR (+) | Pulmonary |
| 2 | 45 M | — | 15 | — | — | — | — | 0 | + | + | ND | ND | 132 | CXR (+) | Pulmonary |
| 3 | 31 M | — | 10 | + | ND | — | SSZ | 5 | — | — | ND | ND | 14 | CXR (+) | Pulmonary |
| 4 | 30 F | — | 10 | + | + | — | SSZ | 0 | — | — | ND | ND | 36 | AFB (+) | Pulmonary |
| 5 | 43 M | — | 6 | + | + | — | — | 0 | — | — | ND | ND | 1 | CXR (+) | Pulmonary |
| 6 | 37 M | — | 6 | — | ND | — | SSZ | 0 | — | — | ND | ND | 60 | CXR (+) | Pulmonary |
| 7 | 29 M | — | 3 | — | + | — | SSZ | 0 | — | — | ND | ND | 15 | CXR (+) | Pleurisy |
| 8 | 45 F | — | 17 | — | — | — | 0 | — | — | ND | ND | 192 | TB-PCR (+) | Intestine | |
| 9 | 41 M | — | 21 | + | + | — | MTX + SSZ | 0 | — | — | ND | ND | 108 | CXR (+) | Pulmonary |
| 10 | 30 M | — | 12 | — | ND | — | — | 1.25 | — | — | ND | ND | 96 | CXR (+) | Pulmonary |
| 1 | 42 M | Infliximab | 17 | + | + | — | MTX + SSZ | 5 | — | — | — | INH 9 mo | 177 (27)** | CXR (+) | Pleurisy |
| 2 | 27 M | Infliximab | 5 | + | + | — | SSZ | 5 | — | — | — | ND | 41 (16) | Chest CT (+) | Miliary |
| 3 | 27 M | Adalimumab | 16 | + | — | — | MTX + SSZ | 0 | + | + | ND | ND | 186 (12) | Chest CT (+) | Pulmonary |
↵* Interval between onset of AS and diagnosis of active TB.
↵** ( ) Interval between starting TNF blockers and diagnosis of active TB. TB: tuberculosis; TNF: tumor necrosis factor; DM: diabetes mellitus; DMARD: disease-modifying antirheumatic drug; CXR: chest radiograph; TST: tuberculin skin test; MTX: methotrexate; SSZ: sulfasalazine; ND: not done; AFB: acid-fast bacilli; TB-PCR: polymerase chain reaction for M. tuberculosis; INH: isoniazid; CT: computed tomography scan.