Comparison of ACA+/PBC screen-positive (23 cases) and ACA+/PBC screen-negative (43 cases).
| Characteristics | ACA+/PBC Screen+, n = 22 | ACA+/PBC Screen–, n = 43 | p |
|---|---|---|---|
| Skin ulcers | 36.3% (8) | 40.5% (17) | NS |
| Telangiectasias | 50% (11) | 75% (30/40) | NS |
| Calcinosis | 13.6% (3) | 28.2% (11/39) | NS |
| Esophageal involvement | 81.8% (18) | 72.5% (29/40) | NS |
| ILD | 13.6% 93) | 9.5% (4) | NS |
| PAH | 18.2% (4) | 7% (3) | NS |
| Renal crisis | 0 | 0 | NS |
| Elevated ALP | 36.3% (8) | 3% (1/32) | 0.002 |
| PBC | 22.7% (5) | 2.4% (1) | 0.014 |
| AMA | 30% (6/20) | 2.5% (1/39) | 0.0047 |
ILD: interstitial lung disease; PAH: pulmonary arterial hypertension; PBC: primary biliary cirrhosis; ALP: alkaline phosphatase; AMA: antimitochondrial antibodies by immunofluorescence; ACA: anticentromere; anti-topo I: antitopoisomerase I; anti-RNAP III: anti-RNA polymerase III.