RA Patients, n = 60 | |||
---|---|---|---|
Characteristic | ACD + IDA, n = 24 | Pure ACD, n = 16 | Nonanemic, n = 20 |
Disease duration, yrs | 9.667 ± 3.655 | 10.25 ± 3.13 | 10.3 ± 2.90 |
DAS28 | 5.36 ± 0.80* | 5.27 ± 0.62* | 3.43 ± 0.64 |
MHAQ | 2.25 ± 0.847* | 2.38 ± 0.72* | 1.5 ± 0.69 |
ESR, mm/h | 45.80 ± 16.70* | 43.75 ± 9.22* | 27.75 ± 6.38 |
hsCRP, mg/l | 8.27 ± 4.58* | 7.47 ± 2.64* | 5.675 ± 2.04 |
Rheumatoid factor, IU/ml | 84.29 ± 39.16 | 78.31 ± 23.98 | 86.9 ± 33.44 |
Total cholesterol, mg/dl | 231.88 ± 31.89 | 235.31 ± 29.92 | 238.75 ± 28.33 |
Triglyceride, mg/dl | 132.83 ± 47.81 | 133.13 ± 47.96 | 127.5 ± 48.73 |
LDL-C, mg/dl | 138.5 ± 26.66 | 138.63 ± 25.83 | 133.9 ± 24.97 |
HDL-C, mg/dl | 42.41 ± 8.97 | 45.94 ± 9.75 | 43.45 ± 9.43 |
TC/HDL-C | 5.59 ± 0.99 | 5.70 ± 1.08 | 5.72 ± 1.12 |
LDL/HDL | 3.05 ± 0.97 | 3.10 ± 0.95 | 2.99 ± 0.94 |
ApoB, g/l | 121.04 ± 9.97 | 122.94 ± 10.44 | 121.85 ± 9.87 |
ApoA-1 g/l | 124.83 ± 18.23 | 125.63 ± 17.65 | 126.55 ± 16.49 |
Hemoglobin, g/dl | 6.06 ± 1.55*,** | 7.25 ± 1.85* | 13 ± 0.73 |
Serum iron, μg/dl | 41.5 ± 20.16* | 49.37 ± 16.9* | 84.5 ± 17.0 |
Ferritin, μg/l | 32.13 ± 17.87*† | 224.37 ± 122.20* | 107.5 ± 5.94 |
TIBC, μg/dl | 415.42 ± 56.80*† | 209.5 ± 43.09* | 230 ± 48.94 |
TfS, % | 13.12 ± 11.55*† | 19.61 ± 12.36* | 24.86 ± 22.23 |
sTfR, μg/ml | 6.22 ± 2.72*† | 2.36 ± 0.64 | 2.16 ± 0.63 |
sTfR-F index | 6.96 ± 4.87*† | 0.9 ± 0.85* | 1.48 ± 0.68 |
Tumor necrosis factor-α, pg/ml | 7.88 ± 3.01* | 7.88 ± 2.99* | 4.88 ± 1.50 |
Interleukin 6, pg/ml | 25.65 ± 12.89*† | 50.69 ± 12.97* | 14.6 ± 4.90 |
Hepcidin, ng/ml | 407.92 ± 109.70*† | 547.5 ± 132.89* | 351.5 ± 132.79 |
CCS, Agatston units | 123.04 ± 118.08† | 140.94 ± 129.22* | 119 ± 118.71 |
↵* p < 0.001 vs nonanemic subgroup;
↵** p < 0.05 vs pure ACD (in RA group);
↵† p < 0.001 vs pure ACD (in RA group). ACD + IDA: anemia of chronic disease with coexistent iron deficiency anemia; pure ACD: pure anemia of chronic disease; MHAQ: Modified Health Assessment Questionnaire; DAS28: Disease Activity Score for 28 joints; ESR: erythrocyte sedimentation rate; hsCRP: high sensitivity C-reactive protein; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; ApoB: apolipoprotein B; TIBC: total iron binding capacity; TfS: transferrin saturation; sTfR-F: serum transferrin receptor/log ferritin; CCS: coronary calcium score.