Proportions of VACTERL association in the EUROCAT database compared to those reported by Carter et al3 (i.e., only anomalies within the spectrum reported by Carter, et al with at least one record in the EUROCAT antiepileptic dataset).
| Carter, et al | EUROCAT Database | ||||
|---|---|---|---|---|---|
| EUROCAT Subgroups* | Major Congenital Anomalies without Chromosomals | Proportion (%) | All VACTERL Records without Chromosomals | Proportion (%) | Prevalence per 10,000 births |
| Total number in group | 31 | 86,290 | |||
| Nervous system | 1 | 3.2 | 8172 | 9.5 | 21.0 |
| Neural tube defects | 1 | 3.2 | 3679 | 4.3 | 9.5 |
| Anencephalus | 1 | 3.2 | 1270 | 1.5 | 3.3 |
| Eye | 1 | 3.2 | 1427 | 1.7 | 3.7 |
| Congenital cataract | 1 | 3.2 | 339 | 0.4 | 0.9 |
| Congenital heart disease† | 7 | 22.6 | 26,650 | 30.9 | 68.7 |
| Ventricular septal defect†† | 1 | 3.2 | 11,971 | 14.9 | 30.8 |
| Atrial septal defect†† | 2 | 6.5 | 8509 | 9.9 | 22.0 |
| Tetralogy of Fallot†† | 1 | 3.2 | 1003 | 1.2 | 2.6 |
| Respiratory | 2 | 6.5 | 1723 | 2.0 | 4.4 |
| Orofacial cleft | 1 | 3.2 | 6033 | 7.0 | 15.5 |
| Cleft palate | 1 | 3.2 | 2369 | 2.7 | 6.2 |
| Digestive system | 3 | 9.7 | 5501 | 6.4 | 14.2 |
| Esophageal atresia†, †† | 1 | 3.2 | 907 | 1.1 | 2.3 |
| Ano-rectal atresia and stenosis †, †† | 1 | 3.2 | 1086 | 1.3 | 2.8 |
| Hirschsprung’s disease†† | 1 | 3.2 | 337 | 0.4 | 0.9 |
| Urinary | 4 | 12.9 | 11,201 | 13 | 28.9 |
| Genital | 3 | 9.7 | 7022 | 8.1 | 18.1 |
| Hypospadia | 3 | 9.7 | 5490 | 6.4 | 14.1 |
| Limb† | 2 | 6.5 | 16,662 | 19.3 | 43.0 |
| Clubfoot without spina bifida | 1 | 3.2 | 3882 | 4.5 | 10.0 |
| Musculoskeletal | 1 | 3.2 | 3239 | 3.8 | 8.3 |