Association of matrix Gla protein (MGP) polymorphism with joint space narrowing and osteophytosis.
| Joint Space Narrowing | ||||
| MGP SNP Genotypes | Crude OR (95% CI) by Dominant Mode | Adjusted OR* (95% CI) by Dominant Mode | Crude OR (95% CI) by Recessive Mode | Adjusted OR* (95% CI) by Recessive Mode |
| rs1800802 (MGP802) | ||||
| AA | } 1.0 | } 1.0 | 0.92 (0.61–1.38) | 1.05 (0.71–1.55) |
| AG | } 1.0 | } 1.0 | ||
| GG | 0.33 (0.13–0.82) | 0.25 (0.11–0.58) | ||
| rs1800801 (MGP801) | ||||
| GG | } 1.0 | } 1.0 | 0.69 (0.45–1.05) | 0.68 (0.46–1.02) |
| AG | } 1.0 | } 1.0 | ||
| AA | 1.23 (0.72–2.10) | 1.39 (0.83–2.35) | ||
| rs4236 (MGP4236) | ||||
| TT | } 1.0 | } 1.0 | 0.53 (0.36–0.81) | 0.52 (0.35–0.78) |
| TC | } 1.0 | } 1.0 | ||
| CC | 1.12 (0.66–1.91) | 1.27 (0.76–2.14) | ||
| Osteophytosis | ||||
| Crude OR Dominant Mode | Adjusted OR* Dominant Mode | Crude OR Recessive Mode | Adjusted OR* Recessive Mode | |
| rs1800802 (MGP802) | ||||
| AA | } 1.0 | } 1.0 | 0.85 (0.55–1.32) | 0.99 (0.65–1.49) |
| AG | } 1.0 | } 1.0 | ||
| GG | 0.42 (0.21–0.85) | 0.31 (0.17–0.58) | ||
| rs1800801 (MGP801) | ||||
| GG | } 1.0 | } 1.0 | 0.85 (0.56–1.30) | 0.85 (0.58–1.28) |
| AG | } 1.0 | } 1.0 | ||
| AA | 1.18 (0.69–2.02) | 1.35 (0.80–2.27) | ||
| rs4236 (MGP4236) | ||||
| TT | } 1.0 | } 1.0 | 0.81 (0.53–1.23) | 0.81 (0.54–1.21) |
| TC | } 1.0 | } 1.0 | ||
| CC | 1.09 (0.64–1.85) | 1.25 (0.75–2.09) | ||
The crude and adjusted OR of joint space narrowing and osteophytosis with polymorphisms of MGP in dominant and recessive modes of inheritance, among older men and women.
↵* Adjusted for age, sex, and body mass index. SNP: single-nucleotide polymorphism.