Table 3.

Associations of baseline knee bone size and cartilage volume with change in knee cartilage volume per year: multivariate analysis. Data are ß 95% CI (%). Bold type denotes statistically significant result.

Multivariable*Multivariable**Multivariable***
Medial tibial cartilage volume change
  Medial tibial bone area
    Per cm2–0.43 (−0.67, −0.19)–0.47 (−0.72, −0.22)0.06 (−0.20, +0.32)
    Per tertile–1.40 (−2.19, −0.61)–1.14 (−2.23, −0.65)−0.31 (−1.08, +0.45)
  Medial tibial cartilage volume
    Per ml–4.00 (−4.91, −3.09)–4.10 (−5.02, −3.17)–4.41 (−5.46, −3.35)
    Per tertile–2.25 (−2.85, −1.64)–2.31 (−2.92, −1.69)–2.35 (−3.01, −1.68)
Lateral tibial cartilage volume change
  Lateral tibial bone area
    Per cm2–0.63 (−0.88, −0.38)–0.62 (−0.88, −0.36)–0.37 (−0.65, −0.08)
    Per tertile–0.90 (−1.51, − 0.28)–0.85 (−1.47, −0.23)−0.26 (−0.90, +0.38)
  Lateral tibial cartilage volume
    Per ml–1.86 (−2.54, −1.19)–1.85 (−2.53, −1.17)–1.37 (−2.13, −0.62)
    Per tertile–1.49 (−2.06, −0.93)–1.50 (−2.07, −0.92)–1.15 (−1.76, −0.55)
Patellar cartilage volume change
  Patellar bone volume
    Per ml−0.02 (−0.19, +0.15)−0.02 (−0.19, +0.15)+0.21 (0.04, +0.39)
    Per tertile−0.30 (−0.97, +0.38)−0.29 (−0.96, +0.39)+0.33 (−0.34, +1.01)
  Patellar cartilage volume
    Per ml–1.19 (−1.72, −0.67)–1.76 (−2.35, −1.17)–2.08 (−2.72, −1.43)
    Per tertile–1.25 (−1.87, −0.64)–1.74 (−2.41, −1.06)–1.93 (−2.64, −1.22)
  • * Adjusted for sex, age, offspring-control status and body mass index.

  • ** Further adjusted for cartilage defects at corresponding site.

  • *** Further adjustment for baseline cartilage volume if baseline bone size, and baseline bone size if baseline cartilage volume.