Longitudinal association of marker levels with granulomatous and vasculitic components of disease activity. Results expressed as increase in disease activity score on the Birmingham Vasculitis Activity Score for Wegener’s Granulomatosis (BVAS/WG) per unit-increase in log-marker level.
| Marker | Crude Association with BVAS/WG | Crude Association with Granulomatous BVAS | Crude Association with Vasculitic BVAS | |||
|---|---|---|---|---|---|---|
| ß Estimate (95% CI) | Std ß | ß Estimate (95% CI) | Std ß | ß Estimate (95% CI) | Std ß | |
| sCD40L | 0.83 (0.42, 1.25) | 0.19 | 0.36 (0.23, 0.49) | 0.26 | 0.20 (−0.03, 0.44) | 0.08 |
| CRP | 0.28 (0.09, 0.47) | 0.10 | 0.18 (0.12, 0.24) | 0.21 | −0.02 (−0.13, 0.10) | −0.01 |
| IL-6 | 0.16 (−0.40, 0.72) | 0.02 | −0.01 (−0.21, 0.18) | 0.00 | 0.13 (−0.22, 0.47) | 0.04 |
| IL-8 | 0.79 (0.45, 1.13) | 0.19 | 0.16 (0.05, 0.27) | 0.12 | 0.47 (0.26, 0.69) | 0.20 |
| MCP-1 | −0.66 (−1.09, −0.24) | −0.13 | −0.42 (−0.59, −0.25) | −0.26 | −0.03 (−0.27, 0.22) | −0.01 |
| P-selectin | 0.81 (0.48, 1.15) | 0.17 | 0.26 (0.12, 0.40) | 0.16 | 0.32 (0.13, 0.51) | 0.12 |
| VEGF | 0.33 (0.09, 0.58) | 0.09 | 0.03 (−0.06, 0.12) | 0.03 | 0.16 (−0.01, 0.33) | 0.08 |
| PR3-ANCA | 0.80 (0.44, 1.16) | 0.17 | 0.12 (−0.02, 0.27) | 0.08 | 0.38 (0.17, 0.59) | 0.15 |
sCD40L: soluble CD40 ligand; CRP: C-reactive protein; IL: interleukin; MCP-1: monocyte chemoattractant protein 1; VEGF: vascular endothelial growth factor; PR3-ANCA: antiproteinase 3 antineutrophil cytoplasmic antibody Std ß: standardized ß estimate.