Criteria | No. Patients Fulfilling Criteria | Accuracy, % | |
---|---|---|---|
WG, n* (%) | MPA, n* (%) | ||
Criteria for WG | |||
1. Biopsy/surrogate measurement for granulomatous inflammation in the respiratory system | 149 (96.1) | 5 (10.9) | 94.5 |
2. Biopsy-verified necrotizing vasculitis in small to medium-size vessels or biopsy/surrogate measurement for glomerulonephritis or positive PR3 ANCA | 146 (94.2) | 46 (100) | 72.6 |
3. Lack of eosinophilia (blood/biopsy samples) | 106 (68.4) | 35 (76.1) | 58.2 |
Patients classified as WG (criteria 1–3 positive) | 92 (59.4) | 3 (6.5) | 67.2 |
Patients classified as WG as modified by Lane, et al15 (criteria 1 and 2 positive) | 133 (85.8) | 5 (10.9) | 86.6 |
Criteria for MPA | |||
1. Biopsy-verified necrotizing vasculitis in small vessels and/or glomerulonephritis with few or no immune deposits | 171 (71.3) | 73 (93.6) | 44.7 |
2. Involvement of > 1 organ system, as indicated by biopsy-verified vasculitis in small to medium-size vessels or a surrogate measurement for glomerulonephritis | 145 (60.4) | 70 (89.7) | 51.9 |
3. Lack of biopsy and surrogate measurement or granulomatous inflammation in the respiratory system | 9 (3.8) | 70 (89.7) | 94.7 |
Patients to be classified as MPA (3/3 criteria positive) | 4 (1.7) | 58 (74.4) | 92.4 |
↵* Results of testing for PR3 ANCA plus determination of eosinophil counts of the peripheral blood were available for 155/240 patients with WG and 46/78 patients with MPA, resulting in a lower number of patients available to test the criteria for WG. WG: Wegener’s granulomatosis; MPA: microscopic polyangiitis; PR3 ANCA: proteinase 3 antineutrophil cytoplasmic antibodies.