Characteristic | Women with SLE, n = 112 | Controls, n = 223 | *p |
---|---|---|---|
Age, yrs | 40 (32–51) | 40 (35–49) | NS |
Body mass index, kg/m2 | 25 (23–30) | 25 (22–29) | NS |
Obesity, % | 26 | 16 | 0.048 |
Systolic blood pressure, mm Hg | 120 (116–128) | 110 (100–120) | 0.005 |
Diastolic blood pressure, mm Hg | 75 (69–82) | 73 (79–80) | NS |
Hypertension, % | 56 | 29 | < 0.001 |
Creatinine, mg/dl | 0.8 (0.7–0.9) | 0.7 (0.6–0.8) | NS |
Total cholesterol, mg/dl | 183 (158–210) | 199 (175–222) | 0.001 |
LDL cholesterol, mg/dl | 104 (77–127) | 124 (103–151) | < 0.001 |
HDL cholesterol, mg/dl | 59 (47–71) | 56 (51–63) | NS |
Triglycerides, mg/dl | 96 (71–122) | 73 (55–101) | 0.001 |
Type 2 diabetes mellitus, % | 4 | 2 | NS |
Smokers, % | 42 | 40 | NS |
Sedentary lifestyle, % | 55 | 49 | NS |
Use of antihypertensives, % | 49 | 11 | < 0.001 |
Use of statins, % | 26 | 3 | < 0.001 |
Disease duration, yrs | 11 (6–17) | — | — |
Renal involvement, % | 37 | — | — |
Anti-dsDNA+, % | 86 | — | — |
Antiphospholipid antibodies, % | 23 | — | — |
Homocystine, μmol/l | 12.9 (11.0–15.1) | — | — |
SLEDAI | 4 (2–6) | — | — |
SDI | 1 (0–2) | — | — |
Prednisone dose, mg/day | 3.75 (0–5) | — | — |
Prednisone, % | 69 | — | — |
Hydroxychloroquine, % | 74 | — | — |
Immunosuppressive agents, % | 33 | — | — |
NSAID, % | 57 | 18 | 0.001 |
↵* Student’s t test for continuous variables; Pearson’s chi-squared test for categorical variables. NS: not significant; LDL: low-density lipoprotein; HDL: high-density lipoprotein; SLEDAI: Systemic Lupus Erythematosus Diseaes Activity Index; SDI: Systemic Lupus International Collaborating Clinics/ACR Damage Index; NSAID: nonsteroid antiinflammatory drugs.