Adjusted regression coefficients (95% CI) for bone marrow lesion (BML) pain severity*. Significant results shown in bold type (p < 0.05).
| Primary Outcome | Secondary Outcomes | ||
|---|---|---|---|
| Total WOMAC Pain | Pain on Walking | Pain on Climbing Stairs | |
| BMLsum | 0.05 (−0.04, 0.14) | 0.11 (−0.01, 0.21) | 0.09 (0.00, 0.18) |
| BMLmax = 0** | 0 | 0 | 0 |
| BMLmax = 1 | 0.20 (−0.18, 0.58) | 0.02 (−0.46, 0.50) | 0.40 (0.02, 0.79) |
| BMLmax = 2 | 0.17 (−0.23, 0.57) | 0.19 (−0.30, 0.69) | 0.35 (−0.06, 0.75) |
| BMLmax = 3 | 0.45 (−0.11, 1.01) | 0.54 (−0.13, 1.20) | 0.60 (0.04, 1.17) |
↵* Regression coefficients were adjusted for age, sex, BMI, OA stage, joint effusion, and meniscal damage.
↵** Regression coefficients for BMLmax = 1–3 were normalized to BMLmax = 0 set at 0. BML: bone marrow lesion; WOMAC: Western Ontario and McMaster Universities OA Index; BMLsum: sum of 6 bone marrow lesion scores; BMLmax: worst BML score at any region; BMI: body mass index.