Numbers of positive chemicals during first screening using HLA-B27 promoter reporter in 293-T cells. Enhancers are chemicals that enhance the luciferase activity to > 150% of baseline; suppressors are those that suppress luciferase activity to < 40% of baseline; positive are either enhancers or suppressors.
| Source of Chemicals | No. Chemicals | No. Enhancers (%) | No. Suppressors (%) | No. Positive (%) |
|---|---|---|---|---|
| BioMol Compound | ||||
| Library | 504 | 1 | 23 | 24 |
| MicroSource SPECTRUM | ||||
| collection | 2000 | 10 | 93 | 103 |
| Prestwick Chemical | ||||
| Library | 1120 | 37 | 122 | 159 |
| UCLA “druggable” | ||||
| compounds | 8640 | 20 | 318 | 338 |
| Totals | 12,264 | 68 (0.6) | 556 (4.5) | 624 (5.1) |
UCLA: University of California at Los Angeles.