Severe forms of mixed cryoglobulinemia. Severe form indicates at least one significant extracutaneous organ involvement.
| Patient | Main Clinical Features at Baseline | Etiology |
|---|---|---|
| 1 | Purpura+++, nephritis, RI, neuropathy, GI bleeding | Essential |
| 2 | Purpura+++, skin ulcers, neuropathy | Essential |
| 3 | Purpura+++, neuropathy, GI bleeding | Essential |
| 4 | Purpura++, neuropathy, nephritis | Essential |
| 5 | Purpura+++, arthralgias, neuropathy, nephritis, RI | Essential |
| 6 | Purpura++, arthralgias, neuropathy, nephritis, RI, GI bleeding | Essential |
| 7 | Purpura++, nephritis | Essential |
| 8 | Purpura+++, RI, skin ulcers, nephritis, arthralgias, neuropathy | Essential |
| 9 | Purpura++, skin ulcers, nephritis, GI bleeding, seizures* | Essential |
| 10 | Purpura+++, arthralgias, neuropathy | Essential |
| 11 | Nephritis, RI, CNS* | Sjögren syndrome |
| 12 | Purpura++, nephritis, RI, arthralgias | Sjögren syndrome |
| 13 | Purpura++, skin ulcers, neuropathy | Rheumatoid arthritis |
| 14 | Purpura++, nephritis, RI, arthritis | Parvovirus B19 |
| 15 | Purpura+, skin ulcers, arthritis, neuropathy | B cell lymphoma |
| 16 | Purpura++, neuropathy, arthralgias | T cell lymphoma |
↵* MRI suggesting cerebral vasculitis. Purpura: + = limited and fluctuating involvement of lower limbs; ++ = persistent and diffuse involvement of lower limbs; +++ = diffuse involvement of lower limbs plus trunk and/or upper limbs. GI: gastrointestinal; RI: renal insufficiency; CNS: central nervous system.