Table 4.

Frequency of VEGFA haplotypes in RA patients with and without ischemic heart disease (IHD) or myocardial infarction (MI).

	All Patients	IHD			MI
VEGFA Haplotype (−2578/−460/+405)	EM Frequency^††	Negative EM Frequency^††	Positive EM Frequency^††	OR (95% CI)	Negative EM Frequency^††	Positive EM Frequency^††	OR (95% CI)
A/C/G	0.483	0.469	0.544	2.37 (1.22–4.62)^†	0.476	0.541	4.10 (1.45–11.59)^†
C/T/C	0.297	0.309	0.242	0.73 (0.49–1.09)^*	0.307	0.217	0.62 (0.37–1.04)^*
C/T/G	0.182	0.190	0.147	0.74 (0.46–1.20)^*	0.185	0.161	0.85 (0.47–1.53)^*
Rare	0.038

↵†† Frequency estimated by the expectation/maximization algorithm. Maximum EM iteration = 500, EM convergence tolerance = 0.0001, frequency threshold = 0.05. Best odds ratio achieved in
↵† dominant model,
↵* additive model.