Comparison of IRF5 haplotypes in patients with systemic juvenile idiopathic arthritis (JIA) with or without MAS. The order of SNP (single-nucleotide polymorphisms) in the haplotype is rs729302-rs2004640-rs2280714.
| Haplotype | Haplotype Frequencies in Patients without MAS | Haplotype Frequencies in Patients with MAS | p | OR | 95% CI |
|---|---|---|---|---|---|
| A-G-C | 0.438 | 0.303 | 0.06 | 1.0 | — |
| C-G-T | 0.330 | 0.182 | 0.04 | 0.92 | 0.35–2.39 |
| A-T-C | 0.017 | 0.015 | 0.93 | 1.19 | 0.08–17.6 |
| A-T-T | 0.201 | 0.485 | < 0.001 | 4.61 | 1.73–12.3 |
IRF5: interferon regulatory factor 5; MAS: macrophage activation syndrome.