Review of literature on pregnancy outcomes after paternal methotrexate exposure.
| Study | Indication | Pregnancy During Male Treatment, n | Dose, mg/wk | Other Treatments | Outcomes | Malformation |
|---|---|---|---|---|---|---|
| Frank8 | Psoriasis | 2 | 25 | 2 normal infants | ||
| Hinkes13 | Leukemia | 1 | Unknown | Mercaptopurine, cyclophosphamide, prednisone | 1 normal infant | |
| Kroner14 | Acute lymphoblastic leukemia | 2 | 25 | Mercaptopurine | 1 normal infant, 1 SA | |
| Weinstein10 | Psoriasis | 2 | 25 | Mercaptopurine | 2 normal infants | |
| Matthews12 | Leukemia | 1 | Unknown | Daunorubicin, cytarabine, thioguanine | 1 normal infant | |
| Perry9 | Reiter’s syndrome | 1 | 25 | 1 normal infant | ||
| Griggs5 | Crohn’s disease | 1 | 25 | 1 normal infant | ||
| Ostensen7 | Rheumatic disease | 10 | Unknown | Etanercept (2 patients) | 7 normal infants, 2 infants with malformation, 1 SA | Atrophy of one hand + small fistula beneath the ear Anomalies of the toes (type not specified) |
| Paschou11 | Ankylosing spondylitis | 2 | Unknown | Infliximab | 2 normal infants | |
| Lamboglia6 | Crohn’s disease | 1 | 10 | Infliximab | 1 normal infant | |
| Total | 23 | 19 normal infants (82.6%) 2 infants with malformation, 2 SA (8.7%) |
SA: spontaneous abortion.